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Article

PGC1α in the kidney

20 Sept 2017

Abstract excerpt

Acute kidney injury (AKI) arising from diverse etiologies is characterized by mitochondrial dysfunction. The peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC1α), a master regulator of mitochondrial biogenesis, has been shown to be protective in AKI. Interestingly, reduction of PGC1α has also been implicated in the development of diabetic kidney disease and renal fibrosis. The beneficial renal...

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PMID: 28931521
DOI: 10.1152/ajprenal.00263.2017

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