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Article

Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway.

Kidney international - 1 Mar 2017

He Xuemin, Cheng Rui, Park Kyoungmin, Benyajati Siribhinya, Moiseyev Gennadiy, Sun Chengyi, Olson Lorin E, Yang Yanhui, Eby Bonnie K, Lau Kai, Ma Jian-Xing

Abstract excerpt

Pigment epithelium-derived factor (PEDF) expression is downregulated in the kidneys of diabetic rats, and delivery of PEDF suppressed renal fibrotic factors in these animals. PEDF has multiple functions including anti-angiogenic, anti-inflammatory and antifibrotic activities. Since the mechanism underlying its antifibrotic effect remains unclear, we studied this in several murine models of renal disease. Renal...

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Identifiers

PMID: 27914705
DOI: 10.1016/j.kint.2016.09.036
PMCID: PMC5313326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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