Article

Selective Modulator of Nuclear Receptor PPARγ with Reduced Adipogenic Potential Ameliorates Experimental Nephrotic Syndrome

2021-09-14

Abstract excerpt

<h4>Background</h4> Glomerular disease, often manifesting as nephrotic syndrome (NS) with high proteinuria, can be refractory to standard treatment and is typically associated with hypoalbuminemia, hypercholesterolemia and hypercoagulopathy. We hypothesized that the nuclear receptor PPARγ can be selectively modulated using a novel partial agonist, GQ-16, to gain therapeutic advantage over traditional PPARγ agonis...

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Literature Corpus work: e15cece3-b8d3-55ca-a610-015bec8be662
DOI: 10.1101/2021.09.14.459479

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Selective Modulator of Nuclear Receptor PPARγ with Reduced Adipogenic Potential Ameliorates Experimental Nephrotic SyndromeDOI 10.1101/2021.09.14.459479Read

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