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Article

Involvement of Striatal Cholinergic Interneurons and M1 and M4 Muscarinic Receptors in Motor Symptoms of Parkinson's Disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Aug 2016

Ztaou Samira, Maurice Nicolas, Camon Jeremy, Guiraudie-Capraz Gaëlle, Kerkerian-Le Goff Lydia, Beurrier Corinne, Liberge Martine, Amalric Marianne

Abstract excerpt

UNLABELLED: Over the last decade, striatal cholinergic interneurons (ChIs) have reemerged as key actors in the pathophysiology of basal-ganglia-related movement disorders. However, the mechanisms involved are still unclear. In this study, we address the role of ChI activity in the expression of parkinsonian-like motor deficits in a unilateral nigrostriatal 6-hydroxydopamine (6-OHDA) lesion model using optogenetic...

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Identifiers

PMID: 27581457
DOI: 10.1523/JNEUROSCI.0873-16.2016
PMCID: PMC6601910

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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