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Article

Pharmacological targeting of dopamine D1 or D2 receptors evokes a rapid-onset parkinsonian motor phenotype in mice.

The European journal of neuroscience - 1 Dec 2024

Del Agua Villa Christian, Atudorei Mihai, Siebner Hartwig Roman, Rickhag Mattias

Abstract excerpt

Dopaminergic nigrostriatal denervation in Parkinson's disease (PD) disrupts the functional balance between striatal projecting neurons, leading to aberrant activity in the cortico-basal ganglia circuit and characteristic motor symptoms. While genetic and toxin-based animal models are commonly used to mimic PD pathology and behaviour, they have limitations when combined with circuit manipulation tools. This...

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Identifiers

PMID: 39626697
DOI: 10.1111/ejn.16622
PMCID: PMC11647426

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