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Motor cortex perineuronal net modulation improves motor function in a Parkinson’s disease mouse model

2024-06-01

Abstract excerpt

The 6-OHDA mouse model recapitulates midbrain dopaminergic cell loss and associated motor deficits akin to those observed in Parkinson’s disease. Emerging evidence suggests that modulating interneurons in the primary motor cortex could offer a means to mitigate symptoms. In the cortex, perineuronal nets (PNNs), a specialized extracellular matrix structure generally present around fast-spiking parvalbumin interneur...

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Literature Corpus work
23b625f6-41c4-5953-bb54-3ccb3856beb4
DOI
10.1101/2024.05.31.596849
Open publication

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Motor cortex perineuronal net modulation improves motor function in a Parkinson’s disease mouse modelDOI 10.1101/2024.05.31.596849
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