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Article

Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response.

International journal of molecular sciences - 26 Oct 2021

Mendes-Pinheiro Bárbara, Soares-Cunha Carina, Marote Ana, Loureiro-Campos Eduardo, Campos Jonas, Barata-Antunes Sandra, Monteiro-Fernandes Daniela, Santos Diogo, Duarte-Silva Sara, Pinto Luísa, José Salgado António

Abstract excerpt

Parkinson's disease (PD) is a prevalent movement disorder characterized by the progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). The 6-hydroxydopamine (6-OHDA) lesion is still one of the most widely used techniques for modeling Parkinson's disease (PD) in rodents. Despite commonly used in rats, it can be challenging to reproduce a similar lesion in mice. Moreover, there is a lack...

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Identifiers

PMID: 34768962
DOI: 10.3390/ijms222111530
PMCID: PMC8584172

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