Article

Cholinergic Transmission in an Inducible Transgenic Mouse Model of Paroxysmal Dystonia

2024-03-17

Abstract excerpt

Altered interaction between striatonigral dopaminergic (DA) inputs and local acetylcholine (ACh) in striatum has long been hypothesized to play a central role in dystonia pathophysiology. Indeed, previous research across various genetic mouse models of human isolated dystonia has identified as a shared endophenotype with paradoxical excitation of striatal cholinergic interneurons (ChIs) activity in response to act...

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Literature Corpus work: 1e08bd9b-a407-5351-b3cc-2b75da7fc410
DOI: 10.1101/2024.03.15.585266

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