Article

M <sub>5</sub> positive allosteric modulation alleviates parkinsonian motor deficits

2025-08-25

Abstract excerpt

Parkinson’s disease is a neurodegenerative movement disorder which is characterized by cardinal motor symptoms of tremor at rest, rigidity, bradykineasia, and postural instability. Underlying these cardinal motor symptoms is thought to be death and dysfunction of nigrostriatal dopamine neurons, and the gold-standard treatment of Parkinson’s disease is dopamine replacement therapy with the dopamine precursor L-DOPA...

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Literature Corpus work: 6c0855f8-bafb-58b9-9a6a-749247c24ea3
DOI: 10.1101/2025.08.21.671539

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