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Article

Knockdown of GAD67 protein levels normalizes neuronal activity in a rat model of Parkinson's disease

1 Mar 2011

Abstract excerpt

BACKGROUND: Dopamine depletion of the striatum is one of the hallmarks of Parkinson's disease. The loss of dopamine upregulates GAD67 expression in the striatal projection neurons and causes other changes in the activity of the basal ganglia circuit. METHODS: To normalize the GAD67 expression in the striatum after dopamine depletion, we developed several lentiviral vectors that express RNA interference (RNAi)...

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PMID: 21449035
DOI: 10.1002/jgm.1555

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