Article
Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jan 2015
Xu Meiyu, Kobets Andrew, Du Jung-Chieh, Lennington Jessica, Li Lina, Banasr Mounira, Duman Ronald S, Vaccarino Flora M, DiLeone Ralph J, Pittenger Christopher
Abstract excerpt
Gilles de la Tourette syndrome (TS) is characterized by tics, which are transiently worsened by stress, acute administration of dopaminergic drugs, and by subtle deficits in motor coordination and sensorimotor gating. It represents the most severe end of a spectrum of tic disorders that, in aggregate, affect ∼ 5% of the population. Available treatments are frequently inadequate, and the pathophysiology is poorly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.