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Article

HtrA Protease Family as Therapeutic Targets

17 Dec 2012

Abstract excerpt

The HtrA proteases degrade damaged proteins and thus control the quality of proteins and protect cells against the consequences of various stresses; they also recognize specific protein substrates and in this way participate in regulation of many pathways. In many pathogenic bacteria strains lacking the HtrA function lose virulence or their virulence is decreased. This is due to an increased vulnerability of...

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PMID: 23016688
DOI: 10.2174/1381612811319060003

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