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Article

The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease.

Nature communications - 12 Sept 2023

Tran Norman, Dasari Sathish, Barwell Sarah A E, McLeod Matthew J, Kalyaanamoorthy Subha, Holyoak Todd, Ganesan Aravindhan

Abstract excerpt

The main protease of SARS-CoV-2 (Mpro) is an important target for developing COVID-19 therapeutics. Recent work has highlighted Mpro's susceptibility to undergo redox-associated conformational changes in response to cellular and immune-system-induced oxidation. Despite structural evidence indicating large-scale rearrangements upon oxidation, the mechanisms of conformational change and its functional consequences...

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Identifiers

PMID: 37699927
DOI: 10.1038/s41467-023-40023-4
PMCID: PMC10497556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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