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Article

HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA.

Biochimica et biophysica acta - 1 Aug 2013

Goo Hui-Gwan, Jung Min Kyo, Han Sung Sic, Rhim Hyangshuk, Kang Seongman

Abstract excerpt

High-temperature requirement protein A2 (HtrA2), a serine protease, localizes in the mitochondria and has diverse roles, including maintenance of mitochondrial homeostasis and regulation of cellular apoptosis. HtrA2 (also known as Omi) is associated with many neurodegenerative diseases, including Parkinson disease. By employing agarose gel electrophoresis, a fluorescent dye, PicoGreen, intercalation into mtDNA,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23542127
DOI: 10.1016/j.bbamcr.2013.03.016

Genes

POLG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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