Article

Intramembrane cleavage of TREM2 is determined by its intrinsic structural dynamics

2019-11-30

Abstract excerpt

Sequence variants of the microglial expressed TREM2 (triggering receptor expressed on myeloid cells 2) are a major risk factor for late onset Alzheimer’s disease. TREM2 requires a stable interaction with DAP12 in the membrane to initiate signaling, which is terminated by TREM2 ectodomain shedding and subsequent intramembrane cleavage by γ-secretase. To understand the structural basis for the specificity of the int...

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Literature Corpus work: 4d520fd6-3f46-50c2-969f-5232353e2b46
DOI: 10.1101/860007

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