Article
Month of birth, HLA-DRB1*15 locus and risk of multiple sclerosis in offspring.
Revista de neurologia - 1 Sept 2016
Guijarro-Castro C, Sanchez-Zapardiel E, Munoz D, Fernandez O, Leyva L, Castro-Panete M J, Picon-Munoz C, Talise M, Martinez-Feito A, Paz-Artal E
Abstract excerpt
INTRODUCTION: A relationship among April births, HLA-DRB1*15:01 genotype and risk of multiple sclerosis (MS) has been described. We aim to determine this association in our cohort of Spanish MS patients. SUBJECTS AND METHODS: We genotyped HLA-DRB1*15:01 allele in 326 MS patients and 226 controls (non-neurological disease patients) by SSP-PCR and compared month of birth with local births during the same period....
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