Article
Vitamin D receptor (VDR) gene SNPs influence VDR expression and modulate protection from multiple sclerosis in HLA-DRB1*15-positive individuals.
Brain, behavior, and immunity - 1 Oct 2011
Agliardi Cristina, Guerini Franca R, Saresella Marina, Caputo Domenico, Leone Maurizio A, Zanzottera Milena, Bolognesi Elisabetta, Marventano Ivana, Barizzone Nadia, Fasano Maria E, Al-Daghri Nasser, Clerici Mario
Abstract excerpt
Multiple sclerosis (MS) is an autoimmune disease with a multifactorial etiology. The HLA-DRB1*15 allele, is the main genetic risk factor for MS in Caucasians; recent findings showed that the transcription of this molecule is regulated by the vitamin D/vitamin D receptor (VDR) complex. We analyzed SNPs within the VDR gene in association with the HLA-DRB1 locus in 641 MS patients diagnosed according to McDonald...
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