HLA-DR 15 is associated with female sex and younger age at diagnosis in multiple sclerosis.

doi:10.1136/jnnp.72.2.184

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Article

HLA-DR 15 is associated with female sex and younger age at diagnosis in multiple sclerosis.

Journal of neurology, neurosurgery, and psychiatry - 1 Feb 2002

Hensiek A E, Sawcer S J, Feakes R, Deans J, Mander A, Akesson E, Roxburgh R, Coraddu F, Smith S, Compston D A S

Abstract excerpt

BACKGROUND: The association between multiple sclerosis and class II alleles of the major histocompatibility complex, in particular the DRB1*1501-DQB1*0602 haplotype, is well established but their role in determining specific features of this clinically heterogeneous disease is unknown as few studies involving large sample sizes have been performed. METHODS: 729 patients with multiple sclerosis were typed for the...

Topics

Adolescent
Adult
Age Factors
Alleles
Cohort Studies
Disability Evaluation
Genetic Carrier Screening
Genetic Predisposition to Disease
HLA-DR Antigens
HLA-DR Serological Subtypes
Humans
Male
Multiple Sclerosis, Chronic Progressive

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multiple Sclerosis, Relapsing-Remitting

Phenotype

Prognosis

Sex Factors

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Identifiers

PMID: 11796767
DOI: 10.1136/jnnp.72.2.184
PMCID: PMC1737743

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