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Article

Human leukocyte antigen-DR15, low infant sibling exposure and multiple sclerosis: gene-environment interaction.

Annals of neurology - 1 Feb 2010

van der Mei Ingrid A F, Ponsonby Arine-Louise, Taylor Bruce V, Stankovich Jim, Dickinson Joanne L, Foote Simon, Kemp Andrew, Dwyer Terence

Abstract excerpt

The risk for development of multiple sclerosis has been associated with human leukocyte antigen-DRB1*1501-DQB1*0602 (HLA-DR15) genotype, low infant sibling exposure, and high Epstein-Barr nuclear antigen IgG levels. In a population-based case-control study (Tasmania, Australia), we found that the combined effect of HLA-DR15 positivity and low infant sibling exposure on multiple sclerosis (odds ratio, 7.88; 95%...

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Identifiers

PMID: 20225292
DOI: 10.1002/ana.21849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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