Article
HLA-DRB1 and month of birth in multiple sclerosis.
Neurology - 15 Dec 2009
Ramagopalan S V, Link J, Byrnes J K, Dyment D A, Giovannoni G, Hintzen R Q, Sundqvist E, Kockum I, Smestad C, Lie B A, Harbo H F, Padyukov L, Alfredsson L, Olsson T, Sadovnick A D, Hillert J, Ebers G C
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) displays a month-of-birth effect, with an excess of individuals being born in the spring and a deficit in the winter. This effect was shown to be more pronounced in familial cases of MS. In the present study, we investigated whether this month-of-birth association has any relation to the principal MS susceptibility gene, HLA-DRB1. METHODS: A total of 4,834 patients with MS,...
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