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Article

Dynamic clonal equilibrium and predetermined cancer risk in Barrett's oesophagus.

Nature communications - 19 Aug 2016

Martinez Pierre, Timmer Margriet R, Lau Chiu T, Calpe Silvia, Sancho-Serra Maria Del Carmen, Straub Danielle, Baker Ann-Marie, Meijer Sybren L, Kate Fiebo J W Ten, Mallant-Hent Rosalie C, Naber Anton H J, van Oijen Arnoud H A M, Baak Lubbertus C, Scholten Pieter, Böhmer Clarisse J M, Fockens Paul, Bergman Jacques J G H M, Maley Carlo C, Graham Trevor A, Krishnadath Kausilia K

Abstract excerpt

Surveillance of Barrett's oesophagus allows us to study the evolutionary dynamics of a human neoplasm over time. Here we use multicolour fluorescence in situ hybridization on brush cytology specimens, from two time points with a median interval of 37 months in 195 non-dysplastic Barrett's patients, and a third time point in a subset of 90 patients at a median interval of 36 months, to study clonal evolution at...

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Identifiers

PMID: 27538785
DOI: 10.1038/ncomms12158
PMCID: PMC4992167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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