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Article

Evolution of neoplastic cell lineages in Barrett oesophagus.

Nature genetics - 1 May 1999

Barrett M T, Sanchez C A, Prevo L J, Wong D J, Galipeau P C, Paulson T G, Rabinovitch P S, Reid B J

Abstract excerpt

It has been hypothesized that neoplastic progression develops as a consequence of an acquired genetic instability and the subsequent evolution of clonal populations with accumulated genetic errors. Accordingly, human cancers and some premalignant lesions contain multiple genetic abnormalities not present in the normal tissues from which the neoplasms arose. Barrett oesophagus (BE) is a premalignant condition...

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Identifiers

PMID: 10319873
DOI: 10.1038/8816
PMCID: PMC1559997

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