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Article

Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress.

Genes & development - 1 Feb 2016

Poli Jérôme, Gerhold Christian-Benedikt, Tosi Alessandro, Hustedt Nicole, Seeber Andrew, Sack Ragna, Herzog Franz, Pasero Philippe, Shimada Kenji, Hopfner Karl-Peter, Gasser Susan M

Abstract excerpt

Little is known about how cells ensure DNA replication in the face of RNA polymerase II (RNAPII)-mediated transcription, especially under conditions of replicative stress. Here we present genetic and proteomic analyses from budding yeast that uncover links between the DNA replication checkpoint sensor Mec1-Ddc2 (ATR-ATRIP), the chromatin remodeling complex INO80C (INO80 complex), and the transcription complex...

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Share to DNA Replication
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Nuclear Proteins

Share to Protein Serine-Threonine Kinases

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Share to Saccharomyces cerevisiae Proteins

Share to Stress, Physiological

Source

Open in PubMed Open full text

Identifiers

PMID: 26798134
DOI: 10.1101/gad.273813.115
PMCID: PMC4743062

Genes

INO80
PAF1
ATR
ATRIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress.PMID 26798134Read ↗

RNAPII-dependent ATM signaling at collisions with replication forks.Semantic proximity Read ↗

Ino80 chromatin remodeling complex promotes recovery of stalled replication forks.Semantic proximity Read ↗

RNA polymerase II contributes to preventing transcription-mediated replication fork stalls.Semantic proximity Read ↗

Actin nucleators safeguard replication forks by limiting nascent strand degradationSemantic proximity Read ↗

H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress.Semantic proximity Read ↗

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Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers.Semantic proximity Read ↗

ATP-dependent chromatin remodeling shapes the DNA replication landscape.Semantic proximity Read ↗

Limiting DNA polymerase delta alters replication dynamics and leads to a dependence on checkpoint activation and recombination-mediated DNA repairSemantic proximity Read ↗

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