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Article

During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks.

The Journal of biological chemistry - 30 Mar 2012

Bustard Denise E, Menolfi Demis, Jeppsson Kristian, Ball Lindsay G, Dewey Sidney Carter, Shirahige Katsuhiko, Sjögren Camilla, Branzei Dana, Cobb Jennifer A

Abstract excerpt

The Smc5/6 complex belongs to the SMC (structural maintenance of chromosomes) family, which also includes cohesin and condensin. In Saccharomyces cerevisiae, the Smc5/6 complex contains six essential non-Smc elements, Nse1-6. Very little is known about how these additional elements contribute to complex function except for Nse2/Mms21, which is an E3 small ubiquitin-like modifier (SUMO) ligase important for Smc5...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22303010
DOI: 10.1074/jbc.M111.336263
PMCID: PMC3322872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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