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Article

Smc5/6 is required for repair at collapsed replication forks.

Molecular and cellular biology - 1 Dec 2006

Ampatzidou Eleni, Irmisch Anja, O'Connell Matthew J, Murray Johanne M

Abstract excerpt

In eukaryotes, three pairs of structural-maintenance-of-chromosome (SMC) proteins are found in conserved multisubunit protein complexes required for chromosomal organization. Cohesin, the Smc1/3 complex, mediates sister chromatid cohesion while two condensin complexes containing Smc2/4 facilitate chromosome condensation. Smc5/6 scaffolds an essential complex required for homologous recombination repair. We have...

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Identifiers

PMID: 17030601
DOI: 10.1128/MCB.01335-06
PMCID: PMC1698528

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Smc5/6 is required for repair at collapsed replication forks.PMID 17030601Read ↗

Smc5/6 maintains stalled replication forks in a recombination-competent conformation.Semantic proximity Read ↗

SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions.Semantic proximity Read ↗

Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites.Semantic proximity Read ↗

SMC5 and MMS21 are required for chromosome cohesion and mitotic progression.Semantic proximity Read ↗

DNA damage checkpoint and recombinational repair differentially affect the replication stress tolerance of Smc6 mutants.Semantic proximity Read ↗

The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages.Semantic proximity Read ↗

Coordination of DNA damage responses via the Smc5/Smc6 complex.Semantic proximity Read ↗

Smc5-Smc6 complex preserves nucleolar integrity in S. cerevisiae.Semantic proximity Read ↗

Anaphase onset before complete DNA replication with intact checkpoint responses.Semantic proximity Read ↗

Incision of damaged DNA in the presence of an impaired Smc5/6 complex imperils genome stability.Semantic proximity Read ↗

SMC complexes and topoisomerase II work together so that sister chromatids can work apart.Semantic proximity Read ↗

H2A.Z-dependent regulation of cohesin dynamics on chromosome arms.Semantic proximity Read ↗

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