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Article

The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.

Molecular and cellular biology - 1 Mar 2006

Pebernard Stephanie, Wohlschlegel James, McDonald W Hayes, Yates John R, Boddy Michael N

Abstract excerpt

Stabilization and processing of stalled replication forks is critical for cell survival and genomic integrity. We characterize a novel DNA repair heterodimer of Nse5 and Nse6, which are nonessential nuclear proteins critical for chromosome segregation in fission yeast. The Nse5/6 dimer facilitates DNA repair as part of the Smc5-Smc6 holocomplex (Smc5/6), the basic architecture of which we define. Nse5-Nse6...

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Identifiers

PMID: 16478984
DOI: 10.1128/MCB.26.5.1617-1630.2006
PMCID: PMC1430260

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The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.PMID 16478984Read ↗

Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.Semantic proximity Read ↗

Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.Semantic proximity Read ↗

During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks.Semantic proximity Read ↗

Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.Semantic proximity Read ↗

Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair.Semantic proximity Read ↗

Coordination of DNA damage responses via the Smc5/Smc6 complex.Semantic proximity Read ↗

Allelic Analysis of smc-6 Reveals Domain-Specific Roles in DNA Repair in Caenorhabditis elegans.Semantic proximity Read ↗

Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.Semantic proximity Read ↗

Smc5/6 Complex Promotes Rad3ATR Checkpoint Signaling at the Perturbed Replication Fork through Sumoylation of the RecQ Helicase Rqh1.Semantic proximity Read ↗

Smc5/6 maintains stalled replication forks in a recombination-competent conformation.Semantic proximity Read ↗

Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE.Semantic proximity Read ↗

Crucial role of the NSE1 RING domain in Smc5/6 stability and FANCM-independent fork progression.Semantic proximity Read ↗

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