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Article

DNA damage checkpoint and recombinational repair differentially affect the replication stress tolerance of Smc6 mutants.

Molecular biology of the cell - 1 Aug 2013

Chen Yu-Hung, Szakal Barnabas, Castellucci Federica, Branzei Dana, Zhao Xiaolan

Abstract excerpt

DNA damage checkpoint and recombinational repair are both important for cell survival of replication stress. Because these two processes influence each other, isolation of their respective contributions is challenging. Research in budding yeast shows that removal of the DNA helicase Mph1 improves survival of cells with defective Smc5/6 complex under replication stress. mph1 is known to reduce the levels of...

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Identifiers

PMID: 23783034
DOI: 10.1091/mbc.E12-11-0836
PMCID: PMC3727935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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DNA damage checkpoint and recombinational repair differentially affect the replication stress tolerance of Smc6 mutants.PMID 23783034Read ↗

Incision of damaged DNA in the presence of an impaired Smc5/6 complex imperils genome stability.Semantic proximity Read ↗

Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites.Semantic proximity Read ↗

Smc5/6 is required for repair at collapsed replication forks.Semantic proximity Read ↗

Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae.Semantic proximity Read ↗

Genetic evidence for a role of Saccharomyces cerevisiae Mph1 in recombinational DNA repair under replicative stress.Semantic proximity Read ↗

Smc5/6 maintains stalled replication forks in a recombination-competent conformation.Semantic proximity Read ↗

Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

Selective modulation of the functions of a conserved DNA motor by a histone fold complex.Semantic proximity Read ↗

Anaphase onset before complete DNA replication with intact checkpoint responses.Semantic proximity Read ↗

Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase.Semantic proximity Read ↗

Profiling DNA damage response following mitotic perturbations.Semantic proximity Read ↗

Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination.Semantic proximity Read ↗

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