Article
Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells.
Genes & development - 1 Aug 2016
Guo Jessie Yanxiang, Teng Xin, Laddha Saurabh V, Ma Sirui, Van Nostrand Stephen C, Yang Yang, Khor Sinan, Chan Chang S, Rabinowitz Joshua D, White Eileen
Abstract excerpt
Autophagy degrades and is thought to recycle proteins, other macromolecules, and organelles. In genetically engineered mouse models (GEMMs) for Kras-driven lung cancer, autophagy prevents the accumulation of defective mitochondria and promotes malignancy. Autophagy-deficient tumor-derived cell lines are respiration-impaired and starvation-sensitive. However, to what extent their sensitivity to starvation arises...
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