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Article

Autophagy sustains glutamate and aspartate synthesis in Saccharomyces cerevisiae during nitrogen starvation.

Nature communications - 4 Jan 2021

Liu Kuanqing, Sutter Benjamin M, Tu Benjamin P

Abstract excerpt

Autophagy catabolizes cellular constituents to promote survival during nutrient deprivation. Yet, a metabolic comprehension of this recycling operation, despite its crucial importance, remains incomplete. Here, we uncover a specific metabolic function of autophagy that exquisitely adjusts cellular metabolism according to nitrogen availability in the budding yeast Saccharomyces cerevisiae. Autophagy enables...

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Identifiers

PMID: 33397945
DOI: 10.1038/s41467-020-20253-6
PMCID: PMC7782722

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