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Article

SREBP1 regulates mitochondrial metabolism in oncogenic KRAS expressing NSCLC.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2020

Ruiz Christian F, Montal Emily D, Haley John A, Bott Alex J, Haley John D

Abstract excerpt

Cancer cells require extensive metabolic reprograming in order to provide the bioenergetics and macromolecular precursors needed to sustain a malignant phenotype. Mutant KRAS is a driver oncogene that is well-known for its ability to regulate the ERK and PI3K signaling pathways. However, it is now appreciated that KRAS can promote the tumor growth via upregulation of anabolic metabolism. We recently reported that...

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Identifiers

PMID: 32568455
DOI: 10.1096/fj.202000052R
PMCID: PMC8335704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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