Article
Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer.
Journal of experimental & clinical cancer research : CR - 17 Jan 2022
Yang Zhang, Liang Shun-Qing, Zhao Liang, Yang Haitang, Marti Thomas M, Hegedüs Balazs, Gao Yanyun, Zheng Bin, Chen Chun, Wang Wenxiang, Dorn Patrick, Kocher Gregor J, Schmid Ralph A, Peng Ren-Wang
Abstract excerpt
BACKGROUND: Oncogenic KRAS mutations are prevalent in human cancers, but effective treatment of KRAS-mutant malignancies remains a major challenge in the clinic. Increasing evidence suggests that aberrant metabolism plays a central role in KRAS-driven oncogenic transformation. The aim of this study is to identify selective metabolic dependency induced by mutant KRAS and to exploit it for the treatment of the...
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