Article

Robustness of the autophagy pathway to somatic copy number losses

2022-04-30

Abstract excerpt

Autophagy allows cells to temporarily tolerate energy stress by replenishing critical metabolites through self-digestion, thereby attenuating the cytotoxic effects of anticancer drugs that target tumor metabolism. Autophagy defects could therefore mark a metabolically vulnerable cancer state and open a therapeutic window. While mutations of autophagy genes (ATGs) are notably rare in cancer, haploinsufficiency netw...

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Literature Corpus work: 55ca968f-2308-5725-bfad-5228a8ba990a
DOI: 10.1101/2022.04.29.489531

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