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Article

Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer.

Nature communications - 12 Jul 2024

Lan Taijin, Arastu Sara, Lam Jarrick, Kim Hyungsin, Wang Wenping, Wang Samuel, Bhatt Vrushank, Lopes Eduardo Cararo, Hu Zhixian, Sun Michael, Luo Xuefei, Ghergurovich Jonathan M, Su Xiaoyang, Rabinowitz Joshua D, White Eileen, Guo Jessie Yanxiang

Abstract excerpt

Cancer cells depend on nicotinamide adenine dinucleotide phosphate (NADPH) to combat oxidative stress and support reductive biosynthesis. One major NADPH production route is the oxidative pentose phosphate pathway (committed step: glucose-6-phosphate dehydrogenase, G6PD). Alternatives exist and can compensate in some tumors. Here, using genetically-engineered lung cancer mouse models, we show that G6PD ablation...

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Identifiers

PMID: 38997257
DOI: 10.1038/s41467-024-50157-8
PMCID: PMC11245543

Genes

G6PD
KL
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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