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Article

Autophagy promotes BrafV600E-driven lung tumorigenesis by preserving mitochondrial metabolism.

Autophagy - 1 Feb 2014

Strohecker Anne M, White Eileen

Abstract excerpt

The role of autophagy in cancer is complex and context-dependent. Here we describe work with genetically engineered mouse models of non-small cell lung cancer (NSCLC) in which the tumor-suppressive and tumor-promoting function of autophagy can be visualized in the same system. We discovered that early tumorigenesis in Braf(V600E)-driven lung cancer is accelerated by autophagy ablation due to unmitigated oxidative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

Source

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Identifiers

PMID: 24362353
DOI: 10.4161/auto.27320
PMCID: PMC5396093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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