Article

Alanine catabolism as a targetable vulnerability for MYC-driven liver cancer

2025-08-01

Abstract excerpt

Liver cancer is a leading cause of cancer-related death world-wide in part due to the shortage of effective therapies, and MYC overexpression defines an aggressive and especially difficult to treat subset of patients. Given MYC’s ability to reprogram cancer cell metabolism, and the liver’s role as a coordinator of systemic metabolism, we hypothesized that MYC induces metabolic dependencies that could be targeted t...

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Literature Corpus work: 02d87c19-5181-501d-b997-c2547438b710
DOI: 10.1101/2025.07.29.667471

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