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Article

Autophagy balances mtDNA synthesis and degradation by DNA polymerase POLG during starvation.

The Journal of cell biology - 7 May 2018

Medeiros Tânia Catarina, Thomas Ryan Lee, Ghillebert Ruben, Graef Martin

Abstract excerpt

Mitochondria contain tens to thousands of copies of their own genome (mitochondrial DNA [mtDNA]), creating genetic redundancy capable of buffering mutations in mitochondrial genes essential for cellular function. However, the mechanisms regulating mtDNA copy number have been elusive. Here we found that DNA synthesis and degradation by mtDNA polymerase γ (POLG) dynamically controlled mtDNA copy number in starving...

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Source

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Identifiers

PMID: 29519802
DOI: 10.1083/jcb.201801168
PMCID: PMC5940314

Genes

POLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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