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Article

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation.

Nature - 29 Jan 2009

Zhu Liqin, Gibson Paul, Currle D Spencer, Tong Yiai, Richardson Robert J, Bayazitov Ildar T, Poppleton Helen, Zakharenko Stanislav, Ellison David W, Gilbertson Richard J

Abstract excerpt

Cancer stem cells are remarkably similar to normal stem cells: both self-renew, are multipotent and express common surface markers, for example, prominin 1 (PROM1, also called CD133). What remains unclear is whether cancer stem cells are the direct progeny of mutated stem cells or more mature cells that reacquire stem cell properties during tumour formation. Answering this question will require knowledge of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19092805
DOI: 10.1038/nature07589
PMCID: PMC2633030

Genes

PROM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation.PMID 19092805Read ↗

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RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis.Semantic proximity Read ↗

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