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Article

Identification of Siglec-1 null individuals infected with HIV-1.

Nature communications - 11 Aug 2016

Martinez-Picado Javier, McLaren Paul J, Erkizia Itziar, Martin Maureen P, Benet Susana, Rotger Margalida, Dalmau Judith, Ouchi Dan, Wolinsky Steven M, Penugonda Sudhir, Günthard Huldrych F, Fellay Jacques, Carrington Mary, Izquierdo-Useros Nuria, Telenti Amalio

Abstract excerpt

Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and infection of bystander target cells. To dissect the role of SIGLEC1 in natura, we scan a large population genetic database and identify a loss-of-function variant (Glu88Ter) that is found in ∼1% of healthy people. Exome analysis and direct genotyping of 4,233 HIV-1-infected individuals reveals two Glu88Ter homozygous and 97...

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Identifiers

PMID: 27510803
DOI: 10.1038/ncomms12412
PMCID: PMC4987525

Genes

SIGLEC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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