Article

Autophagy-enhancing ATG16L1 polymorphism improves clinical outcomes and promotes superior T-cell immunity in chronic HIV-1 infection

2023-03-17

Abstract excerpt

<title>Abstract</title> <p>Chronic HIV-1 infection is characterized by T-cell dysregulation that is only partly restored by antiretroviral therapy. Here, we demonstrate a protective role for autophagy in HIV-1 disease pathogenesis. Targeted analysis of genetic variation in core autophagy gene <italic>ATG16L1 </italic>revealed a previously unidentified polymorphism, which correlated functionally with enhanced auto...

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Literature Corpus work: d8b1bdb0-9de9-5169-99d7-dbb12b8cba80
DOI: 10.21203/rs.3.rs-2616340/v1

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