Article
CD101 genetic variants modify regulatory and conventional T cell phenotypes and functions.
Cell reports. Medicine - 15 Jun 2021
Richert-Spuhler Laura E, Mar Corinne M, Shinde Paurvi, Wu Feinan, Hong Ting, Greene Evan, Hou Sharon, Thomas Katherine, Gottardo Raphael, Mugo Nelly, de Bruyn Guy, Celum Connie, Baeten Jared M, Lingappa Jairam R, Lund Jennifer M
Abstract excerpt
We recently reported that the risk of sexually acquired HIV-1 infection is increased significantly by variants in the gene encoding CD101, a protein thought to modify inflammatory responses. Using blood samples from individuals with and without these variants, we demonstrate that CD101 variants modify the prevalence of circulating inflammatory cell types and show that CD101 variants are associated with increased...
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