Host genetic and immune factors drive evasion of HIV-1 pathogenesis in viremic non-progressors.

doi:10.1016/j.medj.2024.09.007

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Article

Host genetic and immune factors drive evasion of HIV-1 pathogenesis in viremic non-progressors.

Med (New York, N.Y.) - 14 Feb 2025

Bayón-Gil Ángel, Hernández Inmaculada, Dalmau Judith, Nieto Juan C, Urrea Víctor, Garrido-Sanz Lidia, Caratú Ginevra, García-Guerrero Maria C, Gálvez Cristina, Salgado María, Erkizia Itziar, Laguía Fernando, Resa-Infante Patricia, Massanella Marta, Tonda Raúl, Morata Jordi, Hong Kai Ying, Koshy Jane, Goldman Aaron R, Giron Leila, Abdel-Mohsen Mohamed, Heyn Holger, Martinez-Picado Javier, Puertas Maria C

Abstract excerpt

BACKGROUND: Viremic non-progressors (VNPs) represent an exceptional and uncommon subset of people with HIV-1, characterized by the remarkable preservation of normal CD4+ T cell counts despite uncontrolled viral replication-a trait reminiscent of natural hosts of simian immunodeficiency virus. The mechanisms orchestrating evasion from HIV-1 pathogenesis in human VNPs remain elusive, primarily due to the absence of...

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Identifiers

PMID: 39413785
DOI: 10.1016/j.medj.2024.09.007
PMCID: PMC11830539

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CD4
CCR5

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