Article
R5 HIV productively infects Langerhans cells, and infection levels are regulated by compound CCR5 polymorphisms.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2003
Kawamura Tatsuyoshi, Gulden Forrest O, Sugaya Makoto, McNamara David T, Borris Debra L, Lederman Michael M, Orenstein Jan M, Zimmerman Peter A, Blauvelt Andrew
Abstract excerpt
Langerhans cells (LCs) are suspected to be initial targets for HIV after sexual exposure (by becoming infected or by capturing virus). Here, productive R5 HIV infection of LC ex vivo and LC-mediated transmission of virus to CD4+ T cells were both found to depend on CCR5. By contrast, infection of monocyte-derived dendritic cells and transfer of infection from monocyte-derived dendritic cells to CD4+ T cells were...
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