Article
Phenotypic signatures of immune selection in HIV-1 reservoir cells.
Nature - 1 Feb 2023
Sun Weiwei, Gao Ce, Hartana Ciputra Adijaya, Osborn Matthew R, Einkauf Kevin B, Lian Xiaodong, Bone Benjamin, Bonheur Nathalie, Chun Tae-Wook, Rosenberg Eric S, Walker Bruce D, Yu Xu G, Lichterfeld Mathias
Abstract excerpt
Human immunodeficiency virus 1 (HIV-1) reservoir cells persist lifelong despite antiretroviral treatment1,2 but may be vulnerable to host immune responses that could be exploited in strategies to cure HIV-1. Here we used a single-cell, next-generation sequencing approach for the direct ex vivo phenotypic profiling of individual HIV-1-infected memory CD4+ T cells from peripheral blood and lymph nodes of people...
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