Evaluating the Impact of Functional Genetic Variation on HIV-1 Control.

doi:10.1093/infdis/jix470

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Article

Evaluating the Impact of Functional Genetic Variation on HIV-1 Control.

The Journal of infectious diseases - 27 Nov 2017

McLaren Paul J, Pulit Sara L, Gurdasani Deepti, Bartha Istvan, Shea Patrick R, Pomilla Cristina, Gupta Namrata, Gkrania-Klotsas Effrossyni, Young Elizabeth H, Bannert Norbert, Del Amo Julia, Gill M John, Gilmour Jill, Kellam Paul, Kelleher Anthony D, Sönnerborg Anders, Zangerle Robert, Post Frank A, Fisher Martin, Haas David W, Walker Bruce D, Porter Kholoud, Goldstein David B, Sandhu Manjinder S, de Bakker Paul I W, Fellay Jacques

Abstract excerpt

Background: Previous genetic association studies of human immunodeficiency virus-1 (HIV-1) progression have focused on common human genetic variation ascertained through genome-wide genotyping. Methods: We sought to systematically assess the full spectrum of functional variation in protein coding gene regions on HIV-1 progression through exome sequencing of 1327 individuals. Genetic variants were tested...

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Identifiers

PMID: 28968755
DOI: 10.1093/infdis/jix470
PMCID: PMC5853944

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