Article
Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis.
Current opinion in genetics & development - 1 Jun 2016
Safdar Adeel, Annis Sofia, Kraytsberg Yevgenya, Laverack Chloe, Saleem Ayesha, Popadin Konstantin, Woods Dori C, Tilly Jonathan L, Khrapko Konstantin
Abstract excerpt
The mtDNA mutator mouse lacks the proofreading capacity of the sole mtDNA polymerase, leading to accumulation of somatic mtDNA mutations, and a profound premature aging phenotype including elevated oxidative stress and apoptosis, and reduced mitochondrial function. We have previously reported that endurance exercise alleviates the aging phenotype in the mutator mice, reduces oxidative stress, and enhances...
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