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Article

Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice.

Free radical biology & medicine - 1 Oct 2014

Kolesar Jill E, Safdar Adeel, Abadi Arkan, MacNeil Lauren G, Crane Justin D, Tarnopolsky Mark A, Kaufman Brett A

Abstract excerpt

A causal role for mitochondrial dysfunction in mammalian aging is supported by recent studies of the mtDNA mutator mouse ("PolG" mouse), which harbors a defect in the proofreading-exonuclease activity of mitochondrial DNA polymerase gamma. These mice exhibit accelerated aging phenotypes characteristic of human aging, including systemic mitochondrial dysfunction, exercise intolerance, alopecia and graying of hair,...

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Identifiers

PMID: 25106705
DOI: 10.1016/j.freeradbiomed.2014.07.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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