Article
Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2016
Perisic Matic Ljubica, Rykaczewska Urszula, Razuvaev Anton, Sabater-Lleal Maria, Lengquist Mariette, Miller Clint L, Ericsson Ida, Röhl Samuel, Kronqvist Malin, Aldi Silvia, Magné Joelle, Paloschi Valentina, Vesterlund Mattias, Li Yuhuang, Jin Hong, Diez Maria Gonzalez, Roy Joy, Baldassarre Damiano, Veglia Fabrizio, Humphries Steve E, de Faire Ulf, Tremoli Elena, Odeberg Jacob, Vukojević Vladana, Lehtiö Janne, Maegdefessel Lars, Ehrenborg Ewa, Paulsson-Berne Gabrielle, Hansson Göran K, Lindeman Jan H N, Eriksson Per, Quertermous Thomas, Hamsten Anders, Hedin Ulf
Abstract excerpt
OBJECTIVE: Key augmented processes in atherosclerosis have been identified, whereas less is known about downregulated pathways. Here, we applied a systems biology approach to examine suppressed molecular signatures, with the hypothesis that they may provide insight into mechanisms contributing to plaque stability. APPROACH AND RESULTS: Muscle contraction, muscle development, and actin cytoskeleton were the most...
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