Article

Leiomodin 1 deficiency promotes lipid accumulation and redirects gene regulatory programs in smooth muscle cells exposed to oxidized LDL

2026-08-26

Abstract excerpt

<title>Abstract</title> The transition of smooth muscle cells (SMCs) from a contractile to a synthetic, lipid-accumulating phenotype is a central driver of atherosclerosis. We previously identified leiomodin 1 ( <italic>LMOD1</italic> ), an SMC-enriched gene, as a critical regulator of SMC phenotypic modulation and atherosclerosis in mice. However, whether <italic>LMOD1</italic> exerts similar effects in...

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Literature Corpus work: 8d8a04b2-5ed3-5214-a1b6-139f4bd2f680
DOI: 10.21203/rs.3.rs-10473063/v1

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