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Article

Leiomodin 1 haploinsufficiency promotes smooth muscle cell proliferation and increases neointimal lesion size.

Vascular pharmacology - 1 Dec 2025

Wennersten Sara A, Wang Hongxia, Franklin J Lee, Nanda Vivek

Abstract excerpt

The transition of smooth muscle cells (SMCs) from a contractile to a synthetic phenotype is a key contributor to cardiovascular disease (CVD) pathologies, such as atherosclerosis and in-stent restenosis. We previously reported that loss of leiomodin 1 (LMOD1), a coronary artery disease risk gene highly expressed in SMCs, promotes SMC phenotypic switching in vitro. However, the in vivo role of LMOD1 and the...

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Source

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Identifiers

PMID: 41880186
DOI: 10.1016/j.vph.2025.107555
PMCID: PMC13018717

Genes

LMOD1
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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