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Article

Mitogen-activated protein kinase 14 is a novel negative regulatory switch for the vascular smooth muscle cell contractile gene program.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2013

Long Xiaochun, Cowan Sarah L, Miano Joseph M

Abstract excerpt

OBJECTIVE: Several studies have shown through chemical inhibitors that p38 mitogen-activated protein kinase (MAPK) promotes vascular smooth muscle cell (VSMC) differentiation. Here, we evaluate the effects of knocking down a dominant p38MAPK isoform on VSMC differentiation. METHODS AND RESULTS: Knockdown of p38MAPKα (MAPK14) in human coronary artery SMCs unexpectedly increases VSMC differentiation genes, such as...

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Source

Identifiers

PMID: 23175675
DOI: 10.1161/ATVBAHA.112.300645

Genes

MAPK14
SRF
ACTA2
CNN1
LMOD1
MYOCD
TAGLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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